Manchester City duo of Gabriel Jesus and Kyle Walker have contracted COVID-19, the English Premier League side said in a statement on Christmas Day.
Two unnamed staff of the Manchester side were also confirmed to have tested positive for the disease.
“All four personnel will now observe a period of self-isolation in accordance with Premier League and UK Government protocol on quarantine,” the club added.
“Everyone at the Club wishes our colleagues a speedy recovery over the Christmas period ahead of their return to work, training and competition.
The City players join the long-list of sports stars who have tested positive for the disease which has disrupted sporting activities across the world, a development which is set to cause major concern for manager Pep Guardiola ahead of the side’s clash with Newcastle United.